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| transporter associated with antigen processing ： ウィキペディア英語版 |
transporter associated with antigen processing
Transporter associated with antigen processing (TAP) is a member of the ATP-binding-cassette transporter family. It delivers cytosolic peptides into the endoplasmic reticulum (ER), where they bind to nascent MHC class I molecules.
The TAP structure is formed of two proteins: TAP-1 and TAP-2, which have one hydrophobic region and one ATP-binding region each. They assemble into a heterodimer, which results in a four-domain transporter.
==Function==
The TAP transporter is found in the ER lumen associated with the ''peptide-loading complex'' (PLC). This complex of β2 microglobulin, calreticulin, ERp57, TAP, tapasin, and MHC class I acts to keep hold of MHC molecules until they have been fully loaded with peptides.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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